Mechanism of compensatory renal hypertrophy
نویسندگان
چکیده
منابع مشابه
Chemical aspects of compensatory renal hypertrophy.
has been known for over a century that when 1 of the kidneys of a laboratory animal has been surgically removed or is not functioning properly, its partner undergoes a compensatory hypertrophy in which both cell size and cell number increase (20, 21, 33). The mechanism of this compensatory growth is unknown. An obvious possi bility is that it is due to a single kidney having to carry out the wo...
متن کاملFunctional correlates of compensatory renal hypertrophy.
The functional correlates of compensatory renal hypertrophy were studied by micropuncture techniques in rats after the removal of one kidney. The glomerular filtration rate increased to roughly the same extent in the whole kidney and in individual surface nephrons, resulting in a greater amount of sodium delivered to the tubules for reabsorption. The fraction of the glomerular filtrate absorbed...
متن کاملMacromolecular Metabolism in Compensatory Renal Hypertrophy
1. The initial biochemical changes of compensatory hypertrophy occur well within 1 hour of unilateral nephrectomy and perhaps within the first few minutes.2. The initial increment in rRNA is from decreased metabolism rather than from increased synthesis.3. Changes in the processing of mRNA precursors are probably also important.4. Compensatory hypertrophy is regulated by a humoral stimulus or s...
متن کاملMessenger RNA in Compensatory Renal Hypertrophy
Experiments that deal with the stability of messenger RNA (mRNA) in normal mouse kidney, and, to some extent, the stability of mRNA during renal growth will be described. We have found a population of mRNA in the cytoplasm of mouse kidney that is short-lived. Such a class of rapidly metabolized mRNA could play an adaptive role at the translational or cytoplasmic level in determining gene expres...
متن کاملConservation of ribosomal RNA during compensatory renal hypertrophy. A major mechanism in RNA accretion
After removal of one mouse kidney, compensatory hypertrophy in the remaining kidney is marked in 2 days by a 20% average increase in ribosomal RNA (rRNA) per cell. Both 28S and 18S RNA are conserved during the initial stages of compensatory renal hypertrophy to an extent sufficient to account for the rest of the observed accumulation of rRNA. Like some cultured cells, the kidney conserves rRNA ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1971
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1971.sp009675